P Zuchinali et al, 2016. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: a randomized clinical trial. Journal of the American Medical Association, published online.


Relevance:  The presumed proarrhythmic action of caffeine is controversial. Couple of research have assessed the impact of substantial doses of caffeine in patients with heart failure due to left ventricular systolic dysfunction at high threat for ventricular arrhythmias.

Goal:  To compare the result of large-dose caffeine or placebo on the frequency of supraventricular and ventricular arrhythmias, the two at rest and in the course of a symptom-restricted exercising check.
Design and style, Setting, and Participants:  Double-blinded randomized clinical trial with a crossover style performed at the heart failure and cardiac transplant clinic of a tertiary-care university hospital. The trial included patients with continual heart failure with moderate-to-significant systolic dysfunction (left ventricular ejection fraction &lt45%) and New York Heart Association functional class I to III amongst March five, 2013, and October 2, 2015.

Interventions:  Caffeine (100 mg) or lactose capsules, in addition to 5 doses of 100 mL decaffeinated coffee at 1-hour intervals, for a complete of 500 mg of caffeine or placebo in the course of a five-hour protocol. Right after a one-week washout time period, the protocol was repeated.

Major Outcomes and Measures:  Number and percentage of ventricular and supraventricular premature beats assessed by constant electrocardiographic monitoring.

Benefits:  We enrolled 51 individuals (37 [74%] male imply [SD] age, 60.six [10.9] many years) with predominantly moderate-to-severe left ventricular systolic dysfunction (suggest [SD] left ventricular ejection fraction, 29% [7%]) 31 [61%] had an implantable cardioverter-defibrillator gadget. No considerable variations in between the caffeine and placebo groups have been observed in the variety of ventricular (185 vs 239 beats, respectively P = .47) and supraventricular premature beats (6 vs 6 beats, respectively P = .44), as nicely as in couplets, bigeminal cycles, or nonsustained tachycardia in the course of constant electrocardiographic monitoring. Exercising test–derived variables, such as ventricular and supraventricular premature beats, duration of workout, estimated peak oxygen consumption, and heart charge, were not influenced by caffeine ingestion. We observed no increases in ventricular premature beats (91 vs 223 vs 207 beats, respectively) in individuals with larger levels of plasma caffeine concentration compared with reduced plasma levels (P = .91) or with the placebo group (P = .74).

Conclusions and Relevance:  Acute ingestion of higher doses of caffeine did not induce arrhythmias in sufferers with systolic heart failure and at large threat for ventricular arrhythmias.

The publish P Zuchinali et al, 2016. Quick-term effects of large-dose caffeine on cardiac arrhythmias in sufferers with heart failure: a randomized clinical trial. Journal of the American Health care Association, published online. appeared first on Coffee and Overall health.

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