C Yu et al, 2016. An updated dose-response meta-analysis of coffee consumption and liver cancer risk. Scientific Reports published online.

ABSTRACT

Prospective cohort research of the relationship amongst coffee consumption and liver cancer danger have drawn different conclusions. Consequently, a dose-response meta-examination of prospective cohort scientific studies was performed to disentangle this causal partnership. Potential cohort studies of the association in between coffee consumption and liver cancer danger published prior to Jan 9, 2016 had been identified by looking in the PubMed and EMBASE databases. Extracted information were analyzed making use of a random-results model. Of the 2892 records identified using the search approach, a total of twenty cohort studies from 10 publications were incorporated in the ultimate meta-analysis. The pooled estimate of relative chance (RR) with 95% self-assurance interval (CI) for highest vs. non/occasional coffee drinkers was .55(.44–0.67). No evidence of publication bias was observed (p for Egger’s check=.229). Sensitivity examination indicated the final results have been robust. Dose-response examination unveiled a substantial linear dose-response relationship in between coffee consumption and liver cancer chance (p=.36). Subgroup analyses stratified by prespecified variables (gender, geographic region, and adjusted elements) indicated related final results inside person subgroups. Our meta-examination suggested that coffee consumption is inversely connected with liver cancer danger.

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